Genomic view of systemic autoimmunity in MRLlpr mice
نویسندگان
چکیده
منابع مشابه
Systemic autoimmunity in systemic lupus erythematosus: handling of self-antigens
Our understanding of the pathogenesis mechanisms leading to lupus has been augmented by the analysis of several diff erent murine models over the past four decades. Various mouse models of spontaneous lupus have been employed in an eff ort to understand the cellular and genetic mechanisms behind induction of systemic lupus erythematosus (SLE). Th e classic models of spontaneous lupus include th...
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The immune system evolutionarily arises to integrate distant tissues and coordinate responses toward environmental or endogenous threats in complex living beings (1). To this purpose, innate and adaptive immune cells exploit the vast network provided by the vasculature, which enables information exchange and physical communication between threatened tissues and tissues in charge of immune cell ...
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Cell cycle, apoptosis, and replicative senescence are all influenced by the cyclin-dependent kinase inhibitor, p21. It was previously reported that deletion of p21 in 129/Sv x C57BL/6 mixed genetic background mice induced a severe lupus-like disease, almost exclusively in females. However, we did not confirm this finding in an independently derived stock of 129/Sv x C57BL/6 p21(-/-) mice. To fu...
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The diverse genetic backgrounds of lupus-prone murine models, which produce both quantitative and qualitative differences in disease expression, may be a valuable resource for studying the influence of environmental exposure on autoimmune disease in sensitive populations. We tested this premise by exposing autoimmune-prone BXSB and the nonautoimmune C57BL/6 mice to the heavy metal mercury. Alth...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2006
ISSN: 1466-4879,1476-5470
DOI: 10.1038/sj.gene.6364286